PLK1 and adenocarcinoma: Heatmap analysis revealed upregulated VIM and PLK1 mRNA expression in TGF-β-treated adenocarcinoma when the mesenchymal markers CDH2, SNAI1, and SNAI2 were high and either CDH1 or OCLN (epithelial markers) was low in majority of LUAD cells analysed (Fig. 1e).