OTX2 and infection: To evaluate the role of ChP-derived OTX2 in the Otx2-het mice behavior inhibition, we performed a rescue experiment involving ivc injection of AAV serotype 5 encoding Otx2. This serotype provides specific infection of the ChP (Fig. 5a) and resulted in ~1.5-fold increase in Otx2 expression (Fig. 5b, t = 3.525; p = 0.0023).