Monteggia et al. [135] proposed that eEF2K plays a role in mediating the antidepressant-like effects of (R,S)-ketamine, which did not show antidepressant-like effects in Eef2k KO mice; however, it is noted that these mice did not display a depression-like phenotype [136]. The gene discussed is EEF2K; the disease is depressive symptom measurement.