Features of the tumor immune microenvironment (TIME), such as the interaction of nature killer–dendritic cell (DC) axis15, the enrichment of CD8+ T cells, the presence of the galectin-9+ DC/DC-like macrophages, and a high M1/M2 macrophage ratio16 were also reported to be associated with the response to immunotherapy. The gene discussed is CD8A; the disease is neoplasm.