COL21A1, which was recently found to be transcriptomically increased in cardiomyopathy remodeling32, showed large decreases in pCAVS HYP content; in pCAVS, HYPs in known binding motifs of glycoprotein VI were undetected in COL21A1 (Fig. 4D). This evidence concerns the gene COL21A1 and cardiomyopathy.