CHEK2 and neoplasm: As a radiosensitizing lncRNA, LINC-PINT has three characteristics: (i) LINC-PINT acted as a tumor suppressor to mediate cell cycle arrest and apoptosis; (ii) LINC-PINT was responsive to DNA damage, inhibiting DNA damage repair through ATM/ATR-Chk1/Chk2 signaling pathways; (iii) LINC-PINT interacted with DNA-PKcs, which is a key molecule in initiating DDR cascades (Fig. 6e).