In addition, several p14ARF interacting partners such as nucleophosmin (NPM), tumor necrosis factor receptor-associated death domain (TRADD), N-Myc and STATs interactor (NMI), and nucleostemin have also been reported to suppress cell growth or tumor formation through the stabilization of p14ARF by disrupting TRIP12-p14ARF degradation in different cell types including, normal fibroblast, acute myeloid leukemia, lung cancer cell lines, and in a mouse cancer model14–19. This evidence concerns the gene NPM1 and neoplasm.