RAC1 and hepatocellular carcinoma: For instance, Kang et al. supported that YAP1 exhibits oncogenic property in gastric cancer9; Marti et al. revealed that YAP could regulate proliferation, apoptosis, and angiogenesis in human cholangiocarcinoma by functionally interacting with TEAD transcription factors (TEADs)6; Zhou et al. found that YAP upregulation could protect BEL cells from chemotherapy in hepatocellular carcinoma via the RAC1–ROS–mTOR pathway20.