Our findings suggest that YAP promotes the in vivo growth of human CRC cells, and inhibits autophagy both in vitro and in vivo; Bcl-2 expression could be directly upregulated by YAP at the transcriptional level; correspondingly, silencing Bcl-2 expression could alleviate YAP-induced autophagy inhibition. Here, YAP1 is linked to colorectal carcinoma.