KCND3 and interstitial lung disease: Although the pathogenesis of ILD-PH is multifactorial, sustained hypoxia is believed to be one of the most frequent inducers of PH in this group.33 34 Chronic hypoxia may lead to decreased nitric oxide, increased hydrogen peroxide (H2O2, and alterations in voltage-gated K+ channels.33 34 It is conceivable that these mechanisms leading to hypoxic-induced PH operate in an inflammation-independent way and do not involve enhanced B-cell activation.