Numerous factors could elucidate the relationship between obesity and anxiety [83, 84], one of which is immune-inflammatory stimulation, as both conditions increase inflammatory biomarkers, such as C-reactive protein (CRP), interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-α) [83]. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.