Saeed et al. found that patients with MAFLD exhibited increased MLKL levels compared to the non-MAFLD group and that MLKL−/− mice induced with a high-fat diet showed decreased transferase levels, triglycerides, MAFLD activity scores, steatosis score, inflammation, balloon degeneration, and expression of de novo lipogenesis (DNL) genes in the liver [69]. Here, MLKL is linked to steatosis.