The expression and DNA methylation of ISL1 in carcinoma has been studied in many tumors (Dong et al. 1991; Erlenbach-Wunsch et al. 2014; Graham et al. 2013; Kim et al. 2013; Kitchen et al. 2015; Li et al. 2018; Wang et al. 2014; Zhang et al. 2014). Here, ISL1 is linked to carcinoma.