An earlier study by Gyorffy and colleagues analyzed clinical datasets from non-small cell lung cancer in the TCGA database using univariate and multivariate Cox regression analysis, Kaplan-Meier analyses, and found that the expression of CDKN2A, OPN, EZH2, ANXA3, ADAM28 and ERCC1 genes significantly correlated with OS [35]. Here, SPP1 is linked to non-small cell lung carcinoma.