Wang [38] et al. revealed a significant correlation between GREM1 polymorphism rs1258763 and the risk of nonsyndromic orofacial clefts, and Viena CS [39] found that interaction between NTN1 and GREM1 may be associated with the pathogenesis of nonsyndromic cleft lip with or without cleft palate. This evidence concerns the gene GREM1 and cleft lip.