we identified that miR-182 could target the seeding region spanning rs3743104 at the 3′-UTR of GREM1, which suppresses the transcription of GREM1. miR-182 has been reported as a biomarker for kidney injury and bladder cancer, and a regulatory miRNA binding to 3′-UTR of gene targets to the progression of diseases [32, 33]. Here, GREM1 is linked to urinary bladder cancer.