CD40LG and viral infectious disease: Despite upregulation of Th2 transcriptomic signatures in asymptomatic patients, which have been shown to mediate humoral response against viral infections (Spellberg & Edwards, 2001), the SARS‐CoV‐2 spike‐specific IgG responses were comparable between the symptomatic and asymptomatic patients (Fig 4A), while spike‐specific IgM responses were significantly lower in the asymptomatic patients (Fig 4B).