KEGG pathway analysis demonstrated that DE mRNAs in the lncRNA-miRNA-mRNA networks mostly enriched in neurotrophin signaling pathway, apoptosis, chronic myeloid leukemia, insulin signaling pathway, platelet activation pathways according to the P<0.05 (Fig 6B, S20 Table). This evidence concerns the gene BDNF and chronic myelogenous leukemia, BCR-ABL1 positive.