CEP290 and retinal degeneration: To this end, we crossed Nphp1gt/gt mice to Cep290fl/fl;iCre75 mice [25, 30, 31] and compared protein mislocalization and retinal degeneration phenotypes in Nphp1gt/gt;Cep290+/+;iCre75 and Nphp1gt/gt;Cep290+/fl;iCre75 animals: all animals analyzed in this study were iCre75 hemizygotes and iCre75 genotype is omitted for brevity.