BRCA1 and neoplasm: The prevalence of BRCA1/2 alteration across multiple tumor types is presented in Figure 1A. BRCA1/2 altered tumors had higher median (interquartile range [IQR]) TMB (24.59 [9.84-52.14]) than that in wild-type (WT) tumors (5.90 [2.95-10.00]; P < .001) (Figure 1B).