CXCR2 and neoplasm: Previous studies from our group and others have reported that CXC chemokine receptor 2 (CXCR2) plays critical roles in tumor immune evasion and progression.5,6 Further studies are warranted to pinpoint the specific tumor types that are responsive to ICIs when BRCA2 is altered, and to verify whether the addition of CXCR2 inhibition can further improve survival in these patients.