HABP2 and venous thromboembolism: Four protein-altering index variants have previously been associated with cardiovascular health or with muscle development and injury: Firstly, a protein-altering variant in the fibrinolysis-related gene HABP2 (rs7080536) that reduces the activity of the translated protein (25), coagulation factor VII activating protease, and has been associated with carotid stenosis (26) and venous thromboembolism (27).