TNNI3 and chronic obstructive pulmonary disease: We further identified seven phecodes and continuous traits in UK Biobank that were associated with the genetic risk score (GRS) based on the cTnI index variants (n = 12, variance explained = 1.2%) after correction for multiple testing (Fig. 2; Supplementary Material, Tables S15 and S16): cardiac arrhythmias in general, and the sub-phenotype atrial fibrillation and flutter in particular, as well as standing height, aspartate aminotransferase 1, whole body fat free mass, whole body water mass and basal metabolic rate.