Local therapy with either stereotactic radiosurgery (SRS) or whole‐brain radiotherapy for isolated CNS progression during EGFR‐ or ALK‐TKI treatment is recommended29 because in several reported cases, patients with EGFR‐ and ALK‐positive NSCLC who developed isolated CNS progression achieved long PFS following local therapy with the maintenance of the same TKI therapy.22 Here, ALK is linked to non-small cell lung carcinoma.