As shown in Figure 1A, upregulated B2M mRNA expression was observed in LGGs, GBMs, cervical squamous cell carcinoma and endocervical adenocarcinoma, lymphoid neoplasm diffuse large B‐cell lymphoma, esophageal carcinoma, head and neck squamous cell carcinoma, kidney chromophobe, kidney renal clear cell carcinoma, acute myeloid leukemia, pancreatic adenocarcinoma, stomach adenocarcinoma, and testicular germ cell tumors compared with that in corresponding normal tissues. The gene discussed is B2M; the disease is head and neck squamous cell carcinoma.