Albeit no detectable significance between this polymorphism and T2DM, our genotype‐phenotype analyses provided suggestive evidence on a dose‐dependent relation between the number of −174G/C mutant alleles and circulating IL‐6 concentrations, indicating possible implication of IL‐6 gene in the pathogenesis of T2DM. This evidence concerns the gene IL6 and type 2 diabetes mellitus.