Taken together, albeit no detectable significance between IL‐6 gene −174G/C polymorphism and T2DM, our genotype‐phenotype analyses provided suggestive evidence on a dose‐dependent relation between the number of −174G/C mutant alleles and circulating IL‐6 concentrations, indicating possible implication of IL‐6 gene in the pathogenesis of T2DM. The gene discussed is IL6; the disease is type 2 diabetes mellitus.