Aiming to identify potential targets resulting from the depletion of 5‐HT6R and potential mechanistic pathways involved in cognitive impairment in an unbiased manner, we performed RNA sequencing and compared the mRNA profiles of hippocampal tissues from 3‐month‐old adult WT and 5‐HT6R−/− mice (Figure 2). The gene discussed is HTR6; the disease is Cognitive impairment.