CDX2 and Myelodysplasia: The malignant phenotype observed here is more drastic and penetrant than in a recent model leading predominantly to myelodysplasia by targeting CDX2 selectively in hematopoietic stem cells [10], likely because the induction of CDX2 driven by the Mx1Cre allele affects more cells of the hematopoietic lineage than only stem cells.