In the different GBM models studied, we confirmed our previous finding that RXFP1 agonists induced phosphorylated STAT3 at residue Y705 and showed that this STAT3Tyr705 phosphorylation was abolished upon RXFP1 KD, as demonstrated for CTRP8 (Fig. 1I–L; Fig. S1A,C) and RLN2 (Fig. S1H) [45, 59]. Here, STAT3 is linked to glioblastoma.