STAT3 and glioblastoma: We describe a novel CTRP8‐RXFP1‐Janus‐activated kinase 3‐STAT3 signaling cascade that enhances cellular protein content and activity of small Rho GTPase Cdc42, which directs F‐actin cytoskeletal remodeling, filopodia formation, and increased glioblastoma multiforme migration.