The C1Q‐TNF‐related peptide family member C1q tumor necrosis factor‐related peptide 8 (CTRP8) and its G protein‐coupled receptor relaxin family peptide receptor 1 (RXFP1) are emerging as a novel ligand–receptor system that can protect glioblastoma cells against DNA‐alkylating damage and apoptosis. This evidence concerns the gene RXFP1 and glioblastoma.