RXFP1 activation by the secreted adiponectin paralog and RXFP1 agonist C1q tumor necrosis factor‐related peptide 8 (CTRP8) resulted in elevated intracellular cAMP levels and activated PKCζ and PKCδ isoforms in human malignant glioma [45]. The gene discussed is RXFP1; the disease is malignant glioma.