STAT3 and central nervous system cancer: Inhibition of JAK2 activity with AG490 [88, 89], WP1066 [90], sorafenib [91], and WP1193 [92] downregulated STAT3 activity, inhibited proliferation, migratory/ invasive behavior, and focal adhesion kinase signaling of glioma cell lines, and resulted in apoptosis [93].