The consistent upregulation of Cdc42 protein upon CTRP8 treatment is unlikely the result of STAT3 transcriptional activation of the Cdc42 gene, since Cdc42 is not a known STAT3 target gene [97] and CTRP8 did not alter Cdc42 mRNA expression levels in our GBM cells (data not shown). Here, C1QTNF8 is linked to glioblastoma.