CRP and Timothy syndrome: This study demonstrated that the level of involvement, the number of the affected vertebra, the paravertebral soft tissues, the level of IL-6 and CRP, the granuloma, the caseous necrosis, the epithelioid reaction, the microangiosis, the fibrous connective tissue, ANGPTL-4, and MMP-9 might be used markers for determining BS from TS patients.