ZBP1 and viral infectious disease: Consistent with that, RIPK3 can be activated by associating with other two RHIM-containing adaptor proteins such as TRIF and Z-DNA/RNA binding protein 1 (ZBP1; also known as DAI/DLM-1) to mediate necroptosis by TLR3/4 activation and virus infection, respectively [24,27,28].