Several other studies agreed with those findings, observing repeated detection of BAI1 in normal glial cells at both the transcript and protein levels, while failing to detect its presence in GBM cells.66 Consistent with these findings is the observation that BAI1 expression decreases with rising malignancy grades in glioma tumors.67 RNA-seq data from our laboratory show only moderate BAI1 expression in patient-derived GBM cells in vitro (Figure 1A), while it is one of the top 5 detected transcripts in normal brain cells from the Allen Brain Atlas (Figure 1B). The gene discussed is ADGRB1; the disease is central nervous system cancer.