Immunohistochemical analysis confirmed the expression of ELTD1 in vascular-associated cells.113 Li et al. demonstrated that ELTD1 acts by stimulating the JAK/STAT signaling pathway115 and increases the expression of HIF-1α,116 the transcription factor that serves as a master regulator of the hypoxic response and driver of vascularization.117 Since ELTD1 serves as an angiogenic marker, studies have attempted to target the receptor in the hopes of halting tumor vascularization and ultimately progression. This evidence concerns the gene ADGRL4 and neoplasm.