In lower-grade IDH1mut gliomas, we found that the number of PpIX+ putative glioma increased with the number of nestin+ cells (Figure 4H; slope = 0.04 ± 0.01, R2 = 0.65, P = .03, n = 7 IDH1mut gliomas). The gene discussed is NES; the disease is central nervous system cancer.