Overall, the correlation in gene-wide Z between the clinical Alzheimer’s disease8 and Alzheimer’s disease-proxy analyses33 was modest (r ∼0.2), although statistically significant (CD14: P = 2.2 × 10−16, IFN: P = 4.9 × 10−14, LPS2: P = 2.2 × 10−16, LPS24: P = 5.6 × 10−16) (Supplementary Fig. 4). Here, CD14 is linked to early-onset autosomal dominant Alzheimer disease.