The remaining 10 genes (APOE, BIN1, FNBP4, MS4A4A, MS4A6E, MYBPC3, PTK2B, PVR, SPI1 and STX3) are located in published loci significantly associated with Alzheimer’s disease risk from GWAS, giving confidence that we are detecting effects of genuine disease relevance using monocyte TWAS. The gene discussed is MS4A4A; the disease is early-onset autosomal dominant Alzheimer disease.