For three genes in Alzheimer’s disease risk loci from GWAS, PVR, PTK2B and MS4A4E, the TWAS results replicated using independent summary statistics from Marioni et al.33However, for the remaining genes with statistically independent TWAS signals that are in Alzheimer’s disease risk loci, APOE, BIN1, LACTB2, MS4A6E, PLIN2/ADRP and SPI1, we note that the results did not replicate. The gene discussed is APOE; the disease is early-onset autosomal dominant Alzheimer disease.