The data on the association of polymorphisms of the TP53genes Arg72Pro (rs1042522) and MDM2 SNP309 (rs2279744)with the development of tumors as a whole are very contradictory.Therefore, it would be interesting to perform a metaanalysison the association of TP53 Arg72Pro (rs1042522)and MDM2 SNP309 (rs2279744) with a risk of developinglung cancer in Asian and European populations. Here, MDM2 is linked to cancer.