Alterations in immune variables associated withthese disorders may differentially contribute to disease development.Schizophrenia has been found to be accompanied byelevated serum numbers of B-cells, along with a decrease inthe content of T-cells, CD4+ T-helpers, and the ratio of CD4+to CD8+ T-cells (Steiner et al., 2010). This evidence concerns the gene CD8A and schizophrenia.