In our studies, HMMR is associated with breast cancer poor prognosis; it is also known for the relationship with BRCA1 and BRCA2. CKS2, KIF4A, RACGAP1, and SHCBP1 all have positive correlation with HMMR. Therefore, they have the possibility to become combination biomarkers as indicator of prognosis for different subtypes of breast cancer especially TNBC and targets of this disease. The gene discussed is SHCBP1; the disease is breast cancer.