Kegler et al. found that Ala16Val MnSOD (alanine to valine at the 16th amino acid manganese superoxide dismutase) polymorphism has an important role on neuroinflammation maintenance and its consequences, especially the VV genotype in epilepsy patients, increased levels of inflammatory cytokines such as IL-1β and IL-6 [22]. Here, SOD2 is linked to epilepsy.