According to the MREs prediction, the most significantly changed circRNA hsa_circ_0025992 might sponge hsa-miR-20a-3p, a reported angiogenic microRNA targeting vascular endothelial growth factor (Platania et al., 2019; Maisto et al., 2020), and could thus be involved in the endothelial dysfunction of PE. The gene discussed is VEGFA; the disease is endothelial dysfunction.