TP53 and preeclampsia: There is no conflict with the former study that proved that p53 upregulation accelerated G1 arrest and apoptosis of HUVECs from preeclampsia patients (Gao et al., 2016), and a placenta microarray analysis also revealed the overrepresentation of the JAK/STAT pathway in PE (Medina-Bastidas et al., 2020), but little direct evidence explained the dysfunction of HUVECs from PE through the JAK/STAT pathway.