P53 was shown to be acetylated by cAMP-responsive element-binding protein (CREB) (CBP)/p300, which is an acetyltransferase and transcriptional cofactor that serves as a tumor suppressor (Goodman and Smolik, 2000), and CBP/p300-associated factor (pCAF) in response to a variety of cellular stress signals (Brooks and Gu, 2011). The gene discussed is TP53; the disease is neoplasm.