Patients with IP demonstrated higher lymphocytes (3.95 × 109/L vs. 2.59 × 109/L, P < 0.001), including higher CD19+ T cells (0.92 × 109/L vs. 0.51 × 109/L, P < 0.001), CD3+ T cells (2.58 × 109/L vs. 1.69 × 109/L, P < 0.001), CD4+ T cells (1.43 × 109/L vs. 0.90 × 109/L, P < 0.001), and CD8+ T cells (0.91 × 109/L vs. 0.56 × 109/L, P < 0.001) compared with those with PC (Table 1). This evidence concerns the gene CD8A and pachyonychia congenita.