reviewed 715 male breast cancer patients who underwent germline multi-gene panel testing and found that pathogenic variants in CHEK2 (OR = 3.7, p = 6.24 × 10-24) and PALB2 (OR = 6.6, p = 0.01) were both significantly associated with breast cancer risk in men (40). The gene discussed is CHEK2; the disease is breast cancer.