As shown in Table 1, among the twelve established BCSGs, the association of breast cancer risk with ATM, BARD1, BRCA1, BRCA2, CDH1, and CHEK2 was identified in all six genetic sources; PALB2, PTEN, STK11 and TP53 were identified in at least two genetic sources. The gene discussed is BRCA1; the disease is breast cancer.