By functioning as a decoy of fragile X mental retardation protein (FMBP), an RNA binding protein, circZKSCAN1 prevented the binding of FMBP with cell cycle and apoptosis regulator 1 (CCAR1) mRNA and in turn inhibited CCAR1 expression and CCAR1-mediated activation of the Wnt/β-catenin signaling pathway, resulting in compromised stemness in HCC cells (66). The gene discussed is CCAR1; the disease is hepatocellular carcinoma.