For example, an exosomal circRNA, hsa_circ_0070396, was identified as a better diagnostic biomarker than AFP in distinguishing HCCs from healthy controls (AUC: 0.8574 vs. 0.781), and differentiating early HCC patients (with BCLC are 0 or A) from advanced ones (with BCLC are B+C) (AUC: 0.7132 vs. 0.6535) (85). The gene discussed is AFP; the disease is hepatocellular carcinoma.