AFP and cyclic hematopoiesis: Moreover, a combination of those three circRNAs with serum AFP greatly improved the diagnosis potential for HCC in a training set (20 HCCs vs. 20 CH patients; AUC: 0.988, sensitivity: 0.960; specificity: 1.015) and a validation set (180 HCCs vs. 180 CH patients; AUC: 0.955, sensitivity: 0.915; specificity: 0.994) (51).