HPSE2 and neoplasm: Furthermore, NM Hpa2 correlated with an increased number of positive (metastatic) lymph nodes collected at surgery (F=3.5, p = 0.02) (Table 2); Borderline correlation was found between NM Hpa2 and tumor extra thyroid extension (ETE) (Pearson X2 = 6.4, p = 0.09).