AR coactivators, mainly including the p160 steroid receptor coactivator (SRC) family (SRC1, SRC2 and SRC3), chaperone proteins, filamentous actin (f-actin)-binding proteins, DNA repair proteins and ubiquitin ligases, were crucial for PCa progression as well as AIPC conversion (12, 13). This evidence concerns the gene PROS1 and posterior cortical atrophy.