Constitutive activation of NF-κB in ABC-DLBCLs is due to a variety of mutations in NF-κB regulator coding genes, such as MYD88, TNFAIP3 (A20), CD79A/B, CARD11, TRAF2, TRAF5, MAP3K7 (TAK1), or TNFRSF11A (RANK) (5). The gene discussed is NFKB1; the disease is aneurysmal bone cyst.