SMAD4 and colorectal carcinoma: We also found a multitude of oncogenes and tumor suppressor genes in these driver segments that might play an essential role in the tumorigenesis and progression of CRC, such as MYC (8q24.21), CCND3 (6p21.1), ERBB2 (17q12), PTEN (10q23.31), SMAD4 (18q21.2), and APC (5q22.2) (Figure 3B).