PTEN and neoplasm: Cox proportional hazards model demonstrated that SVZ infringement, GTR, PsP, and TERTp mutation were independent prognostic factors for OS (all P < 0.05, Figure 5), while no survival differences were observed in terms of age, gender, tumor size, tumor grade, Ki67 index, expression of TP53, EGFR, MMP-9, and PTEN (Figure 5).