STAM and neoplasm: By comparing STAM1 expression between different ccRCC T stages (pT1 and 2 vs. pT3 and 4) (P = 0.0006, Figure 1C), tumor grade (grade 1 and 2 vs. grade 3 and 4) (P = 0.0001, Figure 1D), and AJCC stages (stage I and II vs. stage III and IV) (P = 0.0002, Figure 1E), the outcomes indicated that a low STAM1 level was significantly correlated with the aggressive features of ccRCC.