However, only pathological stage, lymph node metastasis and FOXO3A protein expression were ultimately determined to be predictors of the OS (P = 0.031, P = 0.006, P = 0.014) and RFS (P = 0.022, P = 0.004, P = 0.010) of UTUC patients in the multivariate analyses (Tables 2, 3). The gene discussed is FOXO3; the disease is metastatic malignant neoplasm in the lymph nodes.