FOXO3 and metastatic malignant neoplasm in the lymph nodes: Univariate analyses determined that pathological stage (both P = 0.008), lymph node metastasis (both P < 0.001), lymphovascular invasion (both P = 0.028), adjuvant therapy (P = 0.025 and P = 0.015) and FOXO3a protein (both P = 0.004) were significantly correlated with both OS and RFS.