However, APA can also act on VEGFR2 expressed in other tissues and organs as other antiangiogenic drugs, which may be responsible for some systemic side effects of APA in clinical practice, including hypertension, proteinuria, hand and foot skin reaction, thrombocytopenia, leukopenia, and neutropenia [23, 24]. This evidence concerns the gene KDR and Decreased total neutrophil count.