We found that the expression of Gab1, TPO, and c-Mpl in the liver tissue of the rats with induced chronic liver failure was significantly lower than that in the normal group (P < 0.05), while their expression was higher following treatment with FYJDHY granules, the difference between the high-dose and the model group being statistically significant (P < 0.05). This evidence concerns the gene GAB1 and chronic liver failure.