The third layer contained psoriasis area and severity index (PASI), body surface area (BSA) [25], squamous cell carcinoma antigen (SCC-Ag), tumor necrosis factor-α (TNF-α), interleukin (IL) and complement levels [26], Dermatology Life Quality Index (DLQI), Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) [27], the scales of Xerostomia Questionnaire (XQ), Cleveland Clinic Score (CCS), and Pittsburgh Sleep Quality Index (PSQI) [28–31]. The gene discussed is TNF; the disease is depressive disorder.