Studies illustrated that miR-182-5p stimulates the proliferation of renal cell carcinoma by activating the AKT/FOXO3a signaling pathway [21]; miR-182-5p hastens the growth of oral squamous cell carcinoma through repressing CAMK2N1 [33]; miR-182-5p eliminates cell proliferation and migration of ovarian cancer via targeting BNIP3 [34]; miR-182-5p alleviates the proliferation and metastasis of colorectal cancer by targeting MTDH [35]. This evidence concerns the gene FOXO3 and oral cavity squamous cell carcinoma.